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目的:探讨安冲汤止血调经的部分作用机理。方法:选育龄期未孕健康雌性SD大鼠,随机分为空白组、安冲汤高、中、低剂量组、止血芳酸对照组。各组实验动物连续灌胃给药15天后处死,检测子宫组织纤溶酶原激活剂(t-PA)、纤溶酶原激活剂抑制物-1(PAI-1)的表达。结果:安冲汤中剂量组与止血芳酸阳性对照组两组t-PA和PAI-1两项指标比较无显著性差异(P>0.05)。结论:安冲汤抑制子宫内膜纤溶系统的活性,促进血液凝固,起到止血调经的作用。
Objective: To investigate some mechanism of action of Anchong Decoction for hemostasis and menstruation. Methods: Healthy female Sprague-Dawley rats were selected and randomly divided into blank control group, high, medium and low doses of Anchong Decoction and hemostatic aromatase control group. The animals in each group were sacrificed 15 days after continuous intragastric administration, and the expressions of t-PA, PAI-1 were detected. Results: There was no significant difference in the two indexes of t-PA and PAI-1 between Zhongchong decoction group and hemostatic aroma positive control group (P> 0.05). Conclusion: Anchuang decoction can inhibit endometrial fibrinolytic system activity, promote blood coagulation and play the role of hemostasis and menstruation.