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目的观察帕利哌酮治疗流浪精神分裂症患儿阴性症状的疗效。方法选择我院收治的流浪精神分裂症儿童28例作为研究对象,治疗开始时对患儿的各种阴性症状进行阴性症状评定量表(SANS)评估后使用帕利哌酮进行治疗,疗程6个月,并在治疗各阶段对临床疗效进行评定对比。结果入组时流浪精神分裂症儿童在SANS 5项因子(思维贫乏;情感平淡或迟钝;意志缺乏/情感淡漠;兴趣缺乏/社交缺乏,注意损害)均处于高分值水平(12.3±1.1,10.4±1.6,14.7±1.0,9.4±1.2,11.8±1.5);经帕利哌酮治疗后患儿各项阴性症状逐渐缓解,治疗结束时5项因子分值与治疗初比较有显著改善(t=29.25,15.66,22.61,17.54,24.57;P<0.01)。结论帕利哌酮能显著改善流浪精神分裂症儿童各种严重的阴性症状。
Objective To observe the curative effect of paliperidone on negative symptoms in children with stray schizophrenia. Methods Totally 28 children with street schizophrenia admitted to our hospital were enrolled in this study. Various negative symptoms of children were evaluated by Negative Symptom Rating Scale (SANS) at the beginning of treatment and then treated with Paliperidone. The course of treatment was 6 Month, and in the treatment of various stages of clinical efficacy assessment comparison. Results Stroke schizophrenia children were at a high score (12.3 ± 1.1, 10.4) in SANS with 5 factors (impaired mood; dull or insensitive mood; apathy / apathy; lack of interest / social lack and attentional impairment) ± 1.6, 14.7 ± 1.0, 9.4 ± 1.2 and 11.8 ± 1.5, respectively). The negative symptoms in children with Paliperidone gradually alleviated. At the end of treatment, the scores of the five factors were significantly improved compared with those at the beginning of treatment (t = 15.66, 22.61, 17.54, 24.57; P <0.01). Conclusion Paliperidone can significantly improve all kinds of serious negative symptoms in children with street schizophrenia.