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目的观察度洛西汀治疗痛性糖尿病神经病变的治疗效果。方法治疗组应用度洛西汀60mg·d~(-1),对照组起始每晚阿米替林25mg,无效逐渐增加剂量到75mg·d~(-1),疗程8周。观察两组疼痛控制情况及治疗前后VAS评分情况。结果两组患者经治疗1周及8周后疗效比较,治疗组好于对照组,差异有统计学意义和高度统计学意义(P<0.05,P<0.01)。治疗1周和8周后,两组VAS疼痛评分比较显示治疗组评分均低于对照组,差异有高度统计学意义(P<0.01)。结论度洛西汀在痛性糖尿病神经病变治疗上有很好的疗效和安全性。
Objective To observe the therapeutic effect of duloxetine on painful diabetic neuropathy. Methods The treatment group was treated with duloxetine 60 mg · d ~ (-1). The control group was started with amitriptyline 25 mg every night, and the dose was gradually increased to 75 mg · d ~ (-1) for 8 weeks. The pain control and the VAS scores before and after treatment were observed. Results The two groups of patients after treatment for 1 week and 8 weeks after treatment, the treatment group was better than the control group, the difference was statistically significant and highly statistically significant (P <0.05, P <0.01). After treatment for 1 week and 8 weeks, the scores of VAS pain score in both groups were significantly lower than those in the control group, the difference was statistically significant (P <0.01). Conclusion Duloxetine has good curative effect and safety in the treatment of painful diabetic neuropathy.