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目的检测高血压脑损害患者血浆Klotho蛋白水平的变化,探讨高血压脑损害的发病机制及相关的危险因素。方法选取本科2007年9月至2008年3月留院观察的高血压、高血压合并脑损害患者及体检中心健康群共190例,分为高血压无脑损害组、高血压脑损害组与正常对照组。检测3组血清Klotho蛋白浓度与血清胆固醇、肌酐、血糖、血压水平,并针对以上因素及年龄和高血压病史等危险因素进行相关性分析。结果正常对照组血清Klotho蛋白浓度[(13.29±4.66)pg/ml]明显高于高血压无脑损害组[(8.66±3.08)pg/ml]与高血压脑损害组[(4.68±2.21)pg/ml](P<0.05),同时高血压无脑损害组明显高于高血压脑损害组(P<0.05)。血清Klotho蛋白浓度与高血压及高血压脑损害患者的胆固醇、肌酐、血糖、血压、年龄、性别以及高血压病史等均存在负相关(r值分别为-0.111、-0.225、-0.289、收缩压-0.428、舒张压-0.211、-0.404、-0.206、-0.516),胆固醇、肌酐、血糖、血压等越高、年龄越大以及高血压病史等越长,血清Klotho蛋白浓度越低。结论血清Klotho蛋白浓度增加可能是高血压及高血压脑损害的保护性因素;高血压患者定期检测血清Klotho蛋白浓度可能有助于早期监测高血压脑损害。
Objective To investigate the changes of Klotho protein in patients with hypertensive brain damage and to explore the pathogenesis and related risk factors of hypertensive brain damage. Methods A total of 190 hypertensive and hypertensive patients with brain damage and physical examination center in our hospital from September 2007 to March 2008 were selected and divided into two groups: hypertensive no brain damage group, hypertensive cerebral injury group and normal group Control group. Serum Klotho protein concentration, serum cholesterol, creatinine, blood sugar and blood pressure were measured in three groups. The correlation analysis was made between the above factors and the risk factors such as age and history of hypertension. Results Serum Klotho protein concentration in normal control group was significantly higher than that in hypertensive cerebral injury group [(13.29 ± 4.66) pg / ml] [(8.66 ± 3.08) pg / ml] / ml] (P <0.05), meanwhile, there was no significant difference between the two groups (P <0.05). Serum Klotho protein concentration was negatively correlated with cholesterol, creatinine, blood glucose, blood pressure, age, sex and history of hypertension in patients with hypertension and hypertensive brain damage (r values were -0.111, -0.225, -0.289, systolic blood pressure -0.428, diastolic blood pressure -0.211, -0.404, -0.206, -0.516). The longer the serum cholesterol, creatinine, blood sugar and blood pressure, the older and the longer the history of hypertension, the lower the serum Klotho protein concentration. Conclusion The increase of serum Klotho protein concentration may be the protective factor of hypertension and hypertensive cerebral damage. Regular serum Klotho concentration in hypertensive patients may be helpful for the early monitoring of hypertensive brain damage.