引言风湿性关节炎(RA)的发病机制虽已得到阐明,但其病因仍不清楚。因此,其治疗仍然是经验性的。治疗 RA 的首选方法是使用非甾体抗炎药(NSAID),以减轻由于炎症引起的疼痛、发热和肿胀。各种结构类型的 NSAID 可能作用于 RA 病理生理过程的不同环节。使用 NSAID和糖皮质激素,虽然症状得到缓解,但关节的损害仍在发展。改善病情的抗风湿药(DMARD)能阻碍或终止内在疾病的进程,但不一定能治愈。目前,美国市场上只有三类合成的 DMARD:金盐,抗疟药氯喹、羟氯喹以及 D-青霉胺。它 INTRODUCTION Although the pathogenesis of rheumatoid arthritis (RA) has been elucidated, its etiology remains unclear. Therefore, its treatment is still empirical. The preferred method of treating RA is the use of non-steroidal anti-inflammatory drugs (NSAIDs) to relieve pain, fever and swelling due to inflammation. Various structural types of NSAIDs may act on different aspects of the pathophysiology of RA. With NSAIDs and glucocorticoids, joint damage is still developing, although the symptoms are relieved. Disease-modifying anti-rheumatic drugs (DMARDs) can hinder or stop the progression of an underlying disease but may not necessarily be curable. Currently, there are only three types of synthetic DMARDs in the U.S. market: gold salts, the antimalarial drugs chloroquine, hydroxychloroquine and D-penicillamine. it