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目的:观察使用天马颗粒剂配合希罗达治疗中晚期大肠癌的临床疗效。方法:对照组予以希罗达每日2510mg/m2,分早晚2次餐后口服,连续2周,间隔1周,每3周重复。每例患者至少2个周期的治疗。治疗组予以天马颗粒剂5克/次,口服,3次/日,4周为1个疗程,配合希罗达治疗。两组均抽取外周血用免疫荧光法检测患者PTEN基因的表达水平。结果:治疗组42例患者中,完全缓解1例,部分缓解14例,稳定23例,进展4例。总有效率为35.7%,疗效高于对照组(P<0.05)。治疗组和对照组都可使患者的PTEN基因表达升高,但治疗组效果更明显,差异有统计学意义(P<0.01)。结论:天马颗粒剂配合希罗达是治疗中晚期大肠癌的有效药物,其不良反应轻微,使用方便,可延长患者的生存期,提高患者的生活质量,具有一定的临床应用前景。
Objective: To observe the use of Pegasus granules with Xeloda in the treatment of advanced colorectal cancer clinical efficacy. Methods: The control group was given Xeloda daily 2510mg / m2, divided into two times a day before and after oral administration, for 2 weeks, 1 week intervals, repeated every 3 weeks. Each patient is treated for at least 2 cycles. The treatment group was given Pegasus Granules 5 g / time, orally, 3 times / day, 4 weeks for a course of treatment, with Xeloda treatment. Peripheral blood was extracted from both groups by immunofluorescence assay PTEN gene expression levels. Results: Among the 42 patients in the treatment group, 1 was completely relieved, 14 were partly relieved, 23 were stable, and 4 were advanced. The total effective rate was 35.7%, the effect was higher than that of the control group (P <0.05). The treatment group and the control group can make the patient’s PTEN gene expression increased, but the treatment group effect is more obvious, the difference was statistically significant (P <0.01). Conclusion: Tianma granule combined with Xeloda is an effective drug for the treatment of advanced colorectal cancer. Its adverse reactions are mild and easy to use, which can prolong the survival of patients and improve the quality of life of patients with certain clinical application prospects.