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辅酶Q_(10)是一种较好的生化药。国外早期应用辅酶Q_(10)治疗坏血病、溃疡、坏死性牙周炎、糖尿病神经炎等已有报道,近来又提出可用于治疗神经性膀胱炎、先天性再生性贫血、肺气肿、支气管性气喘、重症肌无力症、园形脱发症、促进胰腺功能和分泌等。临床应用范围正继续扩大。目前,辅酶Q_(10)是采用提取细胞色素丙以后猪心残渣来提取,生产量有限,尤其是临床需要量日趋扩大的情况下,更显示出提取法的局限性。采用合成法生产辅酶Q_(10),则费用昂贵。所以,应用微生物发酵生产辅酶Q_(10)是提供了另一条有效而廉价的生产工艺路线。
Coenzyme Q_ (10) is a good biochemical medicine. Early application of coenzyme Q_ (10) abroad has been reported for the treatment of scurvy, ulceration, necrotizing periodontitis and diabetic neuritis. Recently, it has also been proposed for the treatment of neuropathic cystitis, congenital regenerative anemia, emphysema, Bronchial asthma, myasthenia gravis, Parkinson’s disease, promote pancreatic function and secretion. Clinical applications are continuing to expand. At present, coenzyme Q_ (10) is extracted from pig heart residue after extraction of cytochrome C, the production is limited, especially when the clinical requirement is expanding day by day, and more shows the limitations of the extraction method. The synthesis of coenzyme Q_ (10), the cost is expensive. Therefore, the application of microbial fermentation of coenzyme Q_ (10) is to provide another effective and cheap production line.