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目的探讨坤泰胶囊改善腹腔镜卵巢巧克力囊肿切除术后卵巢功能的安全性及可行性。方法选择武清区人民医院2015年3月-2016年10月收治的卵巢巧克力囊肿患者,经腹腔镜手术确诊并rAFS分期为Ⅲ~Ⅳ期共93例,术后常规促性腺激素释放激素激动剂(GnRH-a)戈舍瑞林3.6mg,皮下注射,间隔28d注射1次,3个月经周期,随机分为两组,观察组47例术后1个月始口服坤泰胶囊4粒,3次/d,连服3个月;对照组服用安慰剂。观察两组患者术后疼痛缓解程度、低雌激素症状、血清抗苗勒管激素(AMH)水平。结果观察组与对照组腹痛缓解程度,差异无统计学意义(P>0.05),低雌激素症状观察组少于对照组,差异有统计学意义(P<0.05),血清AMH水平观察组高于对照组,差异有统计学意义(P<0.05)。结论坤泰胶囊能够很好的对抗卵巢子宫内膜异位症术后应用GnRH-a引起的低雌激素症状,同时能够改善卵巢的储备功能。
Objective To investigate the safety and feasibility of Kuntai capsule in improving ovarian function after laparoscopic ovarian chocolate cyst excision. Methods The patients with ovarian chocolate cyst admitted in Wuqing District People’s Hospital from March 2015 to October 2016 were diagnosed by laparoscopic surgery and were divided into three stages according to rAFS. A total of 93 cases were treated with conventional gonadotropin-releasing hormone agonist (GnRH-a) goserelin 3.6mg, injected subcutaneously once a day for 28 days and then divided into two groups randomly. In the observation group, 47 patients were given Kuntai capsule 4 Times / d, even for 3 months; control group taking placebo. Postoperative pain relief, hypoestrogenic symptoms and serum anti-Mullerian hormone (AMH) levels were observed in both groups. Results There was no significant difference in the degree of relief of abdominal pain between the observation group and the control group (P> 0.05). The observation group of low estrogen symptom was less than the control group, the difference was statistically significant (P <0.05) Control group, the difference was statistically significant (P <0.05). Conclusions Kuntai Capsule is a good anti-ovarian endometriosis postoperative application of GnRH-a caused by low estrogen symptoms, and can improve the ovarian reserve function.