目的了解正常妊娠早期妇女HbA1c的水平,为妊娠糖尿病(GDM)的早期诊断提供理论基础。方法纳入468例妊娠8～14周孕妇,另纳入125名正常非孕育龄妇女,两组均测定BMI、血红蛋白(Hb)、平均红细胞体积(MCV)、FPG及HbA1c进行组间比较。结果非孕育龄妇女HbA1c水平为(5.45±0.31)%,正常妊娠早期妇女为(5.12±0.25)%,两组间差异有统计学意义(P<0.05)。正常妊娠早期妇女HbA1c水平与年龄、FPG呈正相关(r=0.15,0.25),与MCV呈负相关(r=-0.21),与Hb及BMI无相关性(P>0.05)。结论正常妊娠早期妇女HbA1c的水平低于正常非孕育龄妇女,提示其控制上线为5.6%,当大于此值时可能需早期进行干预或按GDM管理治疗。 Objective To understand the level of HbA1c in early pregnancy and provide a theoretical basis for the early diagnosis of gestational diabetes mellitus (GDM). Methods A total of 468 pregnant women with gestational age from 8 to 14 weeks were enrolled in the study. Another 125 non-pregnant women of reproductive age were recruited. BMI, hemoglobin (Hb), mean corpuscular volume (MCV), FPG and HbA1c were measured in two groups. Results The level of HbA1c was 5.45 ± 0.31% in nonpregnant women and 5.12 ± 0.25% in early pregnant women. There was significant difference between the two groups (P <0.05). The level of HbA1c in normal pregnant women was positively correlated with age and FPG (r = 0.15,0.25), negatively correlated with MCV (r = -0.21), but not with Hb and BMI (P> 0.05). Conclusions The level of HbA1c in early normal pregnant women is lower than that in normal non-pregnant women, suggesting that the control is on-line at 5.6%. When the value is higher than this value, early intervention or GDM management may be needed.