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目的 :探讨雌激素受体 (ER)、孕激素受体 (PR)在原发性胆囊癌组织中的表达及其临床意义。方法 :应用免疫组化 (L SAB)法 ,对 46例胆囊癌及 30例慢性胆囊炎组织中 ER、PR的表达进行检测。结果 :46例胆囊癌组织中 ER、PR的阳性检出率分别为 39.1% (18/ 46 )和 36 .9% (17/ 46 ) ;30例慢性胆囊炎组织中 ER、PR的阳性检出率分别为 13.3% (4 / 30 )和 10 .0 % (3/ 30 ) ,癌与炎性病变之间有明显差异 (P均 <0 .0 5 )。高分化腺癌 ER和 PR的阳性检出率分别为 5 8.3% (14/ 2 4)和 5 4.2 % (13/ 2 4) ,低分化腺癌 ER、PR的阳性检出率均为 18.2 % (4 / 2 2 ) ,二者有显著性差异 (P均 <0 .0 5 )。结论 :检测 ER、PR对了解胆囊癌激素依赖性及指导临床内分泌治疗有意义 ;ER、PR的检测有可能成为评价胆囊癌预后和恶性程度的有用指标
Objective: To investigate the expression and clinical significance of estrogen receptor (ER) and progesterone receptor (PR) in primary gallbladder carcinoma. Methods : The expression of ER and PR in 46 cases of gallbladder carcinoma and 30 cases of chronic cholecystitis were detected by immunohistochemical method (L SAB). RESULTS: The positive detection rates of ER and PR in gallbladder carcinoma tissue were 39.1% (18/46) and 36.9% (17/46) respectively. Positive ER and PR were detected in 30 cases of chronic cholecystitis. The rates were 13.3% (4/30) and 10.0% (3/30), respectively, with significant differences between cancerous and inflammatory lesions (P<0.05). The positive detection rates of ER and PR in well-differentiated adenocarcinomas were 5 8.3% (14/24) and 5 4.2% (13/24) respectively, and the positive detection rates of ER and PR in poorly differentiated adenocarcinomas were 18.2%. (4 / 2 2), there is a significant difference between the two (P all <0.05). Conclusion : Detection of ER and PR is of significance for understanding the hormone dependence of gallbladder cancer and guiding clinical endocrine therapy. The detection of ER and PR may be useful indicators for evaluating the prognosis and malignancy of gallbladder carcinoma.