系统性红斑狼疮(SLE)等自身免疫性疾病是获得性凝血缺陷最常见病因之一。SLE患者产生抗凝血因子Ⅷ抗体时APTT明显升高,称为获得性血友病A(acquired hemophilia A,AHA);而狼疮抗凝物(lupus anticoagulant,LA)作为一种磷脂依赖型病理性抗凝物质,也可导致APTT升高;凝血因子FⅧ抑制物和LA甚至并存于同一患者,两者治疗方式有所不同,临床医师难以判定APTT Autoimmune diseases such as systemic lupus erythematosus (SLE) are among the most common causes of acquired coagulation defects. APTT is significantly elevated in patients with SLE when producing anti-factor Ⅷ antibody, which is called acquired hemophilia A (AHA); and lupus anticoagulant (LA) is a phospholipid-dependent pathological Anticoagulant substances, can also lead to APTT increased; coagulation factor FⅧ inhibitors and LA even coexist in the same patient, the two treatment methods are different, clinicians difficult to determine the APTT