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回顾近年来国外产前筛查唐氏综合征的最新研究进展。从母血清筛查方法、细胞学及分子生物学检查方法和国外采用的最新筛查方法3个方面对产前筛查唐氏综合征系统地进行综述。每种方法各有其优缺点,如母血清筛查方法的特异性不高,细胞学及分子生物学方法的影响因素较多;检测母体血液中的有核红细胞,是目前筛查唐氏综合征的非创伤性方法,为其筛查提供了更好的选择。
Review the recent research progress of Down’s syndrome in prenatal screening in recent years. Three aspects of maternal serum screening method, cytology and molecular biology examination methods and the latest screening methods abroad were reviewed systematically for Down’s syndrome screening of prenatal screening. Each method has its own advantages and disadvantages, such as maternal serum screening method is not specific, cytology and molecular biology methods affect many factors; detection of maternal blood in the nucleated erythrocytes is the screening of Down’s syndrome The non-invasive method of levy provides a better choice for screening.