帕金森病是中老年人常见的中枢神经系统退行性疾病,研究表明小胶质细胞的活化及其介导的神经炎症在帕金森病的病程进展中发挥重要作用,适度干预小胶质细胞的活化有望延缓帕金森病的进程。小胶质细胞是中枢神经系统固有的巨噬细胞,Notch信号途径可以调控小鼠外周巨噬细胞的分化及功能。Notch通路也参与调控小胶质细胞的激活、细胞因子的表达、吞噬活性的变化等,而这与活化的小胶质细胞介导的帕金森病等神经退行性疾病的病情进展相关。因此,本文将综述Notch信号途径与小胶质细胞介导的相关疾病的研究进展。 Parkinson’s disease is a common central nervous system degenerative disease in the elderly. Studies have shown that microglial activation and its mediated neuroinflammation play an important role in the progression of Parkinson’s disease. Moderate intervention of microglia Activation is expected to delay the progression of Parkinson’s disease. Microglia are macrophages intrinsic to central nervous system. Notch signaling pathway can regulate the differentiation and function of peripheral macrophages in mice. Notch pathway is also involved in the regulation of microglial activation, cytokine expression, phagocytic activity changes and so on, which is associated with activation of microglia-mediated Parkinson’s disease and other neurodegenerative diseases. Therefore, this article reviews the progress of the Notch signaling pathway and microglial-mediated diseases.