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应用高压液相色谱(HPLC)法对6只犬腹腔内灌注碳铂(30mg/kg),不同时间取腹腔液、门静脉、外周血测定总铂浓度。结果表明,4小时内腹腔浓度最高,峰值浓度及平均浓度分别为外周血浓度的139倍和64倍,门静脉浓度为外周血浓度的13.3倍和6.5倍.证明腹腔给药可大大提高腹腔、门静脉及肝脏浓度,减低到达体循环量。对有效地杀灭腹腔亚临床转移、门静脉癌栓、防治肝转移十分重要,并对控制术后复发、医源性转移颇有意义。
Six dogs were intraperitoneally injected with carboplatin (30 mg / kg) by high pressure liquid chromatography (HPLC). The concentrations of total platinum in peritoneal fluid, portal vein and peripheral blood were measured at different time points. The results showed that the intraperitoneal concentration was the highest in four hours, the peak concentration and the average concentration were 139 times and 64 times of the peripheral blood concentration respectively, and the portal vein concentration was 13.3 and 6.5 times that of the peripheral blood concentration.It proved that intraperitoneal administration can significantly improve abdominal cavity and portal vein And liver concentration, reduce the volume of body circulation. Effectively kill the subclinical subclinical metastasis, portal vein tumor thrombus, prevention and treatment of liver metastasis is very important, and control of postoperative recurrence, iatrogenic metastasis meaningful.