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目的检测不同糖耐量孕妇血清瘦素、肿瘤坏死因子α(TNFα)、抵抗素水平,探讨脂肪细胞因子与妊娠期糖尿病的关系。方法2004年1月至2005年1月广州医学院附属省妇儿医院采用放免法检测正常糖耐量(NGT)孕妇38例、糖耐量减低(GIGT)孕妇33例和妊娠期糖尿病(GDM)孕妇37例的血清瘦素和TNFα;利用酶免法检测三组孕妇的血清抵抗素。结果(1)血清瘦素水平由NGT组到GIGI组和GDM组呈显著增高(P<0.01),瘦素与空腹胰岛素(FINS)、胰岛素抵抗指数(HOMAIR)、胰岛β细胞功能指数(HBCI)呈显著性正相关(P<0.05～0.01)。(2)血清TNFα由NGT组到GIGI组和GDM组呈显著性增高(P<0.01),TNFα与FBG、FINS、HOMAIR存在显著性正相关。(3)GDM组和GIGT组血清抵抗素水平显著高于NGT组(P<0.01)。结论GDM和GIGT组患者血清瘦素、TNFα和抵抗素水平增高,脂肪细胞因子与妊娠期糖尿病的发生密切相关。
Objective To detect the levels of serum leptin, tumor necrosis factor α (TNFα) and resistin in different glucose tolerance pregnant women and to explore the relationship between adipocytokines and gestational diabetes mellitus. Methods From January 2004 to January 2005, 38 pregnant women with normal glucose tolerance (NGT), 33 pregnant women with impaired glucose tolerance (GIGT) and 30 pregnant women with gestational diabetes (GDM) 37 Cases of serum leptin and TNFα; enzyme immunoassay for serum resistin in three groups of pregnant women. Results Serum leptin levels were significantly increased from NGT group to GIGI group and GDM group (P <0.01). The levels of leptin, FINS, HOMAIR, HBCI, There was a significant positive correlation (P <0.05 ~ 0.01). (2) Serum TNFα was significantly increased from NGT group to GIGI group and GDM group (P <0.01). There was a significant positive correlation between TNFα and FBG, FINS and HOMAIR. (3) Serum resistin levels in GDM group and GIGT group were significantly higher than those in NGT group (P <0.01). Conclusions Serum leptin, TNFα and resistin levels are elevated in GDM and GIGT patients. The adipocytokines are closely related to the occurrence of gestational diabetes mellitus.