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目的探讨严重脓毒症在凝功能障碍早期抗凝治疗上给予临床分析。方法选取52例严重脓毒症患者,对照组应用常规方法行脓毒症治疗,观察组在常规治疗基础上加用小剂量普通肝素。结果对照组和观察组在治疗第1天和第7天PT、APTT、PLT比较差异无统计学意义。2组治疗第7天TXB2、APACHEII评分比较差异有统计学意义(P<0.05)。结论对于严重脓毒症患者早期应用小剂量肝素能影响到患者的APACHEII(急性生理与慢性健康评分及血栓烷素TXB2的值,对判断脓毒症患者预后有着一定价值。
Objective To investigate the clinical analysis of severe sepsis in the early anticoagulant therapy of coagulation disorders. Methods Fifty-two patients with severe sepsis were selected. The control group was treated with sepsis by the conventional method. The observation group was given low-dose unfractionated heparin on the basis of routine treatment. Results There was no significant difference in PT, APTT and PLT between the control group and the observation group on the 1st and 7th day of treatment. The TXB2 and APACHEII scores on the 7th day of treatment in the two groups were significantly different (P <0.05). Conclusion Early application of low-dose heparin in patients with severe sepsis can affect APACHEII (Acute Physiology and Chronic Health Score and thromboxane TXB2 values, which is of value in judging the prognosis of patients with sepsis.