论文部分内容阅读
目的探讨人乳头状瘤病毒L1蛋白(HPV L1壳蛋白)预测宫颈上皮内瘤变程度及转归的价值以指导宫颈病变的临床处理。方法选择在漯河医学高等专科学校第一附属医院就诊的高危型HPV(HR-HPV)阳性的312例妇女,进行TCT检查并行HPV L1蛋白检测,对病理证实为宫颈上皮内瘤变(CIN)的192例妇女随访2年。结果最终病理证实CINⅠ92例,CINⅡ63例,CINⅢ37例。CINⅠ患者中HPV L1壳蛋白阳性率高于CINⅡ、CINⅢ(P<0.05),HPV L1壳蛋白阳性率与宫颈疾病的严重程度呈负相关(rs=-0.325)。未手术组中,HPV L1蛋白(+)患者的病变转阴率高于LHPV L1蛋白(-)患者,差异有统计学意义(P<0.05)。CINⅠ中,HPV L1蛋白(+)患者的病变转阴率高于LHPV L1蛋白(-)患者(P<0.05),CINⅡ中,未手术组HPV L1蛋白(+)患者的病变转阴率高于LHPV L1蛋白(-)患者(P<0.05)。结论结合HR-HPV检查和宫颈细胞学检查,HPV L1壳蛋白检测可以预测宫颈上皮内瘤变程度及其临床转归。
Objective To investigate the value of human papillomavirus L1 protein (HPV L1 capsid protein) in predicting cervical intraepithelial neoplasia and prognosis to guide the clinical treatment of cervical lesions. Methods A total of 312 high-risk HPV (HR-HPV) -positive women who were treated at the First Affiliated Hospital of Luohe Medical College were tested for TCT and HPV L1 protein. The pathological findings of cervical intraepithelial neoplasia (CIN) 192 women were followed up for 2 years. Results The final pathology confirmed CIN Ⅰ 92 cases, CIN Ⅱ 63 cases, CIN Ⅲ 37 cases. The positive rate of HPV L1 capsid protein in CINⅠ patients was higher than that of CINⅡ and CINⅢ (P <0.05). The positive rate of HPV L1 capsid protein was negatively correlated with the severity of cervical diseases (rs = -0.325). In non-operation group, the rate of pathological change of HPV L1 protein (+) patients was higher than that of LHPV L1 protein patients (P <0.05). In CINⅠ, the rate of pathological change of HPV L1 protein (+) was higher than that of LHPV L1 protein (-) (P <0.05). In CINⅡ, the rate of pathological change of HPV L1 protein LHPV L1 protein (-) patients (P <0.05). Conclusion Combined with HR-HPV test and cervical cytology, HPV L1 capsid protein can predict the degree of cervical intraepithelial neoplasia and its clinical outcome.