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细菌对抗药物的耐药机制是多样性的,虽经多年研究,但尚未阐明。耐药机制的深入研究,提供了对细菌特性演化的了解。在美国波士顿举行的11届国际化疗会议和19届抗菌药物和化疗国际会议中,曾讨论了各种β-内酰胺酶及其他了解较少的耐药机制问题。 Bryan等人一直在研究对青霉素和氨基糖苷类低水平染色体耐药的机制。他们指出肺炎球菌对青霉素的耐药性是由于青霉素不能与细胞膜上的青霉素结合蛋白相结合。用十二烷基硫酸钠厚片凝胶电泳分离得到的耐药菌的膜蛋白,显示有三种青霉素结合蛋白。与这些蛋白质的结合程度与耐药水平呈反比。虽然这些蛋白质对其他抗生素很少提供交叉耐药性,但有
Bacterial drug resistance mechanisms are diverse, although after years of research, but not yet elucidated. An in-depth study of the mechanism of resistance has provided insight into the evolution of bacterial properties. In the 11th International Conference on Chemotherapy and the 19th International Conference on Antibiotics and Chemotherapy in Boston, USA, various β-lactamases and other less understood mechanisms of resistance were discussed. Bryan et al. Have been studying mechanisms of resistance to low levels of penicillin and aminoglycoside chromosomes. They pointed out that pneumococcal resistance to penicillin is due to penicillin can not be combined with the cell membrane penicillin binding protein. Membrane proteins of resistant bacteria isolated from lamellar sodium sulfate slab gel electrophoresis showed three penicillin binding proteins. The degree of binding to these proteins is inversely proportional to the level of resistance. Although these proteins rarely provide cross-resistance to other antibiotics, there are