目的：研究脑缺血再灌流后海马区ｃＧＭＰ的变化。方法：钳夹沙土鼠的双侧颈总动脉制造脑缺血模型．应用双重免疫荧光染色法染色。结果：脑缺血再灌流后，ｃＧＭＰ迅速短暂地增高，ｃＧＭＰ阳性细胞主要分布在海马木部的始层、放射层及腔隙分子层，ｃＧＭＰ阳性细胞多数是呈形胶质细胞。结论：ｃＧＭＰ阳性细胞可能通过ｃＧＭＰ的功效对脑缺血起保护作用。ｃＧＭＰ阳性细胞可能对脑缺血耐受。 Objective: To study the changes of cGMP in hippocampus after cerebral ischemia and reperfusion. Methods: The bilateral common carotid arteries of the gerbil were used to make the cerebral ischemia model. Apply double immunofluorescence staining. Results: After transient focal cerebral ischemia and reperfusion, cGMP rapidly and transiently increased. The cGMP positive cells mainly distributed in the apical layer, the radioactive layer and the lacunar molecular layer in the hippocampus, and most of the cGMP positive cells were the astrocytes. Conclusion: cGMP positive cells may play a protective role in cerebral ischemia through the effect of cGMP. cGMP-positive cells may be resistant to cerebral ischemia.