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目的 探讨新型的质子泵H+ 、K+ —ATP酶抑制剂奥美拉唑 (商品名洛赛克LOSEC)对小儿上消化道出血的治疗效果。方法 采用交叉设计的方法把 90例就诊的上消化道出血的患儿分为治疗组和对照组。治疗组在常规治疗的基础上加用奥美拉唑 ,对照组仅采用常规治疗 ,治疗前后分别检测肝肾功能。结果 治疗组显效 2 2 2 2 % ,有效66 67% ,无效 1 1 1 1 % ,总有效率 88 89%。对照组显效 6 67% ,有效 53 33 % ,无效 40 % ,总有效率 60 % ,两组数据经统计学处理 ,差异非常显著 (P <0 0 1 )。未所有病例治疗前后肝肾功能无明显改变。但有 1例患儿出现便秘 ,是由于家长误将奥美拉唑 ,一日一次用成一日二次所致 ,未发现其它毒副作用。结论 用奥美拉唑短程疗法 (3～ 5d)治疗小儿上消化道出血疗效显著 ,明显高于对照组常规疗法 ,且无明显毒副作用及肝肾功能影响 ,值得推广应用
Objective To investigate the therapeutic effect of novel proton pump H +, K + -ATPase inhibitor omeprazole (Losec LOSEC) on children with upper gastrointestinal bleeding. Methods 90 cases of upper gastrointestinal bleeding were divided into treatment group and control group by cross design method. The treatment group was given omeprazole on the basis of routine treatment, while the control group was only treated with routine treatment, liver and kidney function were detected before and after treatment. Results The treatment group showed a significant effect of 2222%, effective 66 67%, ineffective 1111%, and total effective rate 88 89%. In the control group, the effective rate was 6 67%, the effective rate was 53 33%, the ineffective 40% and the total effective rate 60%. The data of two groups were statistically significant (P <0.01). Not all cases of liver and kidney function before and after treatment no significant change. However, one case of constipation in children is due to parents mistakenly put omeprazole, once a day due to the second day, did not find any other side effects. Conclusion Omeprazole short-course therapy (3 ~ 5d) treatment of children with upper gastrointestinal bleeding was significantly higher than the control group conventional therapy, and no obvious side effects and liver and kidney function, it is worth promoting the application