作者报告5例弥漫性曲菌性肺炎,病变发展迅速,患者最终死亡,有别于较常见的局限型空洞内继发曲菌球。该病为急性或亚急性型,起病突然,有发热、败血症等临床症状。发展极为迅速。X线表现为单侧或双侧弥漫性肺炎,广泛浸润,并可见融合;分层片更清晰,病灶迅速坏死形成空洞。依据痰液真菌培养和血清免疫电泳作出诊断。本组5例作痰液培养,3例发现烟色曲菌;4例作血清免疫电泳,3例阳性。血白细胞计数可明显增高,且以嗜中性粒细胞为主。抗菌素及皮质激素治疗无效。患者往往全身或/及肺部抵抗力降低,本组患者年龄61～80岁。全身情况较差者3例。慢性支气管炎、严重肺气肿者3例。有1例于7年前曾因肺空洞 The authors report 5 cases of diffuse aspergillosis pneumonia, the rapid development of the disease, the patient eventually died, different from the more common confined cavity within the secondary germ ball. The disease is acute or subacute type, sudden onset, fever, sepsis and other clinical symptoms. The development is extremely rapid. X-ray showed unilateral or bilateral diffuse pneumonia, extensive infiltration, and visible fusion; layered tablets more clearly, the rapid necrosis of the lesions to form a cavity. Based on sputum fungal culture and serum immunoelectrophoresis to make a diagnosis. The group of 5 cases sputum culture, 3 cases of Aspergillus flavus; 4 cases of serum immunoelectrophoresis, 3 cases were positive. Blood leukocyte count can be significantly increased, and mainly neutrophils. Antibiotics and corticosteroids are ineffective. Patients are often systemic or / and lung resistance decreased in this group of patients aged 61 to 80 years. 3 cases of poor general condition. Chronic bronchitis, severe emphysema in 3 cases. There was 1 case of pneumothorax 7 years ago