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目的探讨2型糖尿病患者幽门螺杆菌(HP)感染与血管病变的关系。方法分析214例2型糖尿病患者的下肢血管多普勒超声表现及血脂、脂蛋白、内皮素(ET)含量。结果①本文2型糖尿病患者HP阳性率为56.5%(122/216),阴性率为42.6%(92/216),可疑率为0.9%(2/216)。②122例HP感染者经四联疗法HP根治率为59.0%。③2型糖尿病患者不论是否伴有HP感染,其总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、ET水平均明显高于正常对照组(P(0.01),高密度脂蛋白胆固醇(HDL-C)水平明显低于正常对照组(P(0.01);HP阳性组较HP阴性组上述改变更明显,根治HP后根治组TC、TG、LDL-C、ET水平明显下降(P(0.01),HDL-C水平明显升高(P(0.01);HP阳性组下肢血管血管病变的轻度、中度、重度发生率明显高于HP阴性组(P(0.05);HP阳性组TC、TG、LDL-C与ET水平呈正相关,HDL-C与ET水平呈负相关。结论 2型糖尿病患者HP感染率高,而HP根治率不理想,2型糖尿病患者存在患血管病变的高危险性,而HP感染更加重了这种高风险,根治HP有利于降低其危险性。
Objective To investigate the relationship between Helicobacter pylori (HP) infection and vascular diseases in type 2 diabetic patients. Methods Vascular Doppler echocardiography, blood lipid, lipoprotein and endothelin (ET) contents in 214 patients with type 2 diabetes mellitus were analyzed. Results ① The positive rate of HP in type 2 diabetic patients was 56.5% (122/216), the negative rate was 42.6% (92/216) and the suspicious rate was 0.9% (2/216). ② 122 cases of HP infected by quadruple therapy HP cure rate was 59.0%. ③The levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and ET in patients with type 2 diabetes mellitus were significantly higher than those in controls (P <0.01) , High-density lipoprotein cholesterol (HDL-C) levels were significantly lower than the normal control group (P (0.01); HP positive group than the HP-negative group more obvious changes in the radical group after radical treatment of TC, TG, LDL-C, ET (P <0.01). The levels of HDL-C in HP-positive group were significantly higher than those in HP-negative group (P <0.05) ; There was a positive correlation between the levels of TC, TG, LDL-C and ET in HP positive group, but negative correlation between HDL-C and ET level.Conclusion The HP infection rate in type 2 diabetes patients is high, but the cure rate of HP is not ideal, patients with type 2 diabetes High risk of vascular disease, and HP infection more severe this high risk, radical HP is conducive to reduce the risk.