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目的探讨C反应蛋白(CRP)对小儿急性呼吸道感染的鉴别诊断效果。方法选择内江市市中区妇幼保健院门诊2015年1—6月收治的小儿急性呼吸道感染患儿,根据血液、咽分泌物培养和血清学检测将患儿分为肺炎支原体感染、呼吸道细菌感染、呼吸道病毒感染组,各50例,另抽取同期来我院体检的健康儿童50例作为对照组。回顾性分析其临床资料,比较各组的CRP水平。结果急性期,呼吸道细菌感染组CRP水平高于其他各组,差异有统计学意义(P<0.05);肺炎支原体感染组CRP水平高于病毒感染组和对照组,差异有统计学意义(P<0.05);病毒感染组与对照组CRP水平比较,差异无统计学意义(P>0.05)。肺炎支原体感染组与呼吸道细菌感染组CRP阳性率高于对照组与病毒感染组,差异有统计学意义(P<0.05)。恢复期肺炎支原体感染组与呼吸道细菌感染组患儿的血清CRP水平及CRP阳性率低于急性发病期,差异有统计学意义(P<0.01)。结论血清CRP可作为临床甄别肺炎支原体感染与呼吸道细菌感染、病毒感染的依据,还可作为感染疗效的评定标准。
Objective To investigate the differential diagnosis of acute respiratory infection in children with C-reactive protein (CRP). Methods Neonatal children with acute respiratory tract infection were admitted to Neihua Maternal and Child Health Care Hospital in Neijiang City from January to June, 2015. The children were divided into Mycoplasma pneumoniae infection, respiratory tract bacterial infection, Respiratory virus infection group, each 50 cases, while the other to take the same period in our hospital physical examination of 50 healthy children as a control group. The clinical data were retrospectively analyzed and the levels of CRP in each group were compared. Results In the acute phase, the CRP level in respiratory tract bacterial infection group was higher than other groups (P <0.05). The CRP level in mycoplasma pneumoniae infection group was higher than that in virus infection group and control group (P < 0.05). There was no significant difference in CRP level between virus infected group and control group (P> 0.05). The positive rate of CRP in Mycoplasma pneumoniae infection group and respiratory tract bacterial infection group was higher than that in control group and virus infection group, the difference was statistically significant (P <0.05). The serum levels of CRP and the positive rate of CRP in convalescent pneumonia mycoplasma infection group and respiratory tract bacterial infection group were lower than those in acute onset stage, the difference was statistically significant (P <0.01). Conclusion Serum CRP can be used as the basis for clinical screening of Mycoplasma pneumoniae infection and respiratory tract bacterial infection and viral infection, and can be used as the evaluation standard of infection efficacy.