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目的:探讨化疗药物对心脏损伤的心电图Q-T离散度(Q-Td)及校正的Q-T离散度(Q-Tcd)的影响。方法:以化疗后心电图出现ST-T改变为观察组(n=40),化疗后心电图没有出现ST-T改变为对照组(n=40),比较两组化疗前后心电图Q-Td和Q-Tcd的变化。结果:两组化疗前心电图Q-Td和Q-Tcd值无明显差异(P>0.05);观察组化疗后较化疗前Q-Td和Q-Tcd值均显著延长(P<0.05),而对照组化疗前后无显著变化。结论:化疗引起ST-T改变提示化疗前患者可能有冠状动脉病变或冠状动脉储备功能不良,该类患者Q-Td明显增加,提示其恶性心律失常或不良心脏事件的发生可能增加,应引起关注。
Objective: To investigate the effects of chemotherapeutic drugs on Q-T dispersion and Q-T dispersion (Q-Td) of electrocardiogram in cardiac injury. Methods: ST-T changes of electrocardiogram after chemotherapy were observed in the observation group (n = 40). After the chemotherapy, ST-T was not changed to the control group (n = 40) Tcd changes. Results: There was no significant difference in Q-Td and Q-Tcd values between the two groups before chemotherapy (P> 0.05). The Q-Td and Q-Tcd values in the observation group were significantly longer than those before chemotherapy (P <0.05) There was no significant change in the group before and after chemotherapy. Conclusions: The change of ST-T caused by chemotherapy suggests that patients with coronary artery disease or coronary reserve dysfunction may be found before chemotherapy. The Q-Td in these patients is significantly increased, which indicates that the incidence of malignant arrhythmia or adverse cardiac events may be increased and should be paid attention .