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关于锂(Li~+)的生物学作用的一些事实已得到论证。第一,由于锂的物理化学性质,故它在生物学环境内的表现非常类似Na~+和 K~+。这就是它为什么可以部分地或不完全地取代 Na~+、K~+的原因。锂通过 Na~+交换进入细胞,并代替 Na~+与糖和氨基酸一起直接沿蛋白通道流动。它可干扰各种细胞功能(例如离子膜的选择性和激素反应)。第二,Li~+能以下述方式作用于中枢神经系统:干扰神经细胞离子流和儿茶酚胺代谢,这就解释了它在治疗狂躁病上的有益作用。第
Some facts about the biological role of lithium (Li ~ +) have been demonstrated. First, because of the physico-chemical properties of lithium, it behaves very similarly in Na ~ + and K ~ + within the biological environment. This is why it can partially or completely replace Na ~ +, K ~ +. Lithium is exchanged into the cell by Na ~ + and instead of Na ~ + it flows directly along the protein channel together with sugars and amino acids. It can interfere with a variety of cellular functions (such as membrane selectivity and hormone response). Second, Li ~ + acts on the central nervous system in a manner that interferes with the ion fluxes of the nerve cells and catecholamine metabolism, which explains its beneficial effect in the treatment of mania. No.