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结直肠粘膜每 3～ 4天全部更新一次，肿瘤组织细胞更新更快 [1]，因此，收集浓缩肠道灌洗液可得到肠道脱落细胞。由于脱落细胞在肠道存留时间短，细胞可能保持完整， DNA结构可能未被破坏，进行肠道脱落细胞细胞学检查及癌相关基因突变检测就有可能发现恶性肿瘤并由此做出诊断?
The colorectal mucosa is completely renewed every 3 to 4 days, and the tumor tissue is more rapidly renewed [1]. Therefore, intestinal exfoliated cells can be obtained by collecting concentrated intestinal lavage fluid. Since the exfoliated cells have a short residence time in the intestine, the cells may remain intact, and the DNA structure may not be destroyed. It is possible to detect malignancy by performing cytological examination of intestinal exfoliated cells and detection of cancer-related gene mutations.