恶性脑瘤由于呈浸润性生长,与正常脑组织分界不清,手术难以全切,而且有些深部肿瘤不适合外科手术治疗,因此,化学药物已成为恶性脑瘤综合治疗的重要手段之一。但目前临床上常用的化疗方法结果不尽理想,原因是血脑屏障的存在以及化疗药物的毒性反应限制了化疗药物在靶区的浓度,从 Malignant brain tumors are infiltrative growth, with unclear boundaries between normal brain tissue, surgery is difficult to cut, and some deep tumors are not suitable for surgical treatment, therefore, chemical drugs have become an important means of comprehensive treatment of malignant brain tumors. However, currently the clinically used chemotherapy methods are not ideal, because the presence of the blood-brain barrier and the toxicity of chemotherapeutic drugs limit the concentration of chemotherapeutic drugs in the target area.