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碘摄入被疑为甲状腺癌发生的危险因素。在轻度缺碘地区和中度缺碘地区,这种差别伴随有50%的甲状腺肿和甲状腺毒症发病率差异。地区间甲状腺癌发病率差异关联国家补碘计划的安全。研究1973年~1997年丹麦报道的所有甲状腺癌,主要是4种亚型:乳突状癌、滤泡状癌、未分化癌和髓样癌。使用泊松回归模型和年龄、期间、性别适合度模型来分析。所有的滤泡状癌[0.3/(10万人.年)]或乳突状癌[0.7/(10万人.年)]的发病率2个地区间无地域差异;均观察到甲状腺癌总发病率轻微上升,但并无显著意义,这主要是由于乳突状癌发病率显著升高所致。研究结论认为,适度碘摄入的差异并不影响甲状腺癌的发生或是其亚型的分布。
Iodine intake was suspected to be a risk factor for thyroid cancer. In mildly iodine-deficient areas and moderately iodine-deficient areas, this difference is accompanied by a 50% difference in the incidence of goiter and thyrotoxicosis. Regional differences in the incidence of thyroid cancer are associated with the safety of the national iodine supplementation program. Studies of all thyroid cancers reported in Denmark from 1973 to 1997 were mainly four subtypes: papillary, follicular, undifferentiated, and medullary. The Poisson regression model and the age, period, and gender fitness models were used for analysis. The incidence of all follicular carcinoma [0.3/(100,000 person-years)] or papillary carcinoma [0.7/(100,000 person-years)] was not geographically different between the two regions; total thyroid cancer was observed. The incidence rate rose slightly, but it was not significant. This was mainly due to a significant increase in the incidence of papillary carcinoma. The study concluded that the difference in moderate iodine intake does not affect the occurrence of thyroid cancer or the distribution of its subtypes.