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已知怀孕及口服避孕药(OC)对类风湿性关节炎(RA)的发病有影响,怀孕后RA的病情可缓解,但关于怀孕及OC对RA预后的最终影响尚未清楚。作者经过12年随访研究了RA患者怀孕及OC对其关节是否会有放射学损害及致残影响。 方法 选择138例确诊的女性RA患者,均符合1987年美国风湿病学院的RA诊断标准,其中6例失访,余132例共随访12年。112例患者(85％)手脚小关节放射学损害应用Sharp评分标准,大关节损害应用Larsen评分标准,用健康评估调查表(HAQ)评价RA的功
It is known that pregnancy and oral contraceptives (OC) have an impact on the onset of rheumatoid arthritis (RA), and the condition of RA after pregnancy can be alleviated. However, the ultimate impact of pregnancy and OC on the prognosis of RA remains unclear. After a 12-year follow-up, the authors investigated the effects of pregnancy and OC on radiographic damage and disability in RA patients. Methods A total of 138 RA patients diagnosed were selected, all of whom were in accordance with the RA diagnostic criteria of the American College of Rheumatology in 1987, of whom 6 were lost and 132 were followed up for 12 years. 112 patients (85%) Radiographic damage of the hands and feet facet joints using the Sharp score criteria, large joint damage using Larsen score criteria, the use of health assessment questionnaire (HAQ) evaluation of RA work