宫颈癌是严重威胁女性健康的第二大恶性肿瘤,在发展中国家其发病率和死亡率约占女性所有恶性肿瘤的15%,严重影响了妇女及其家庭的生活质量。近年来,宫颈癌患病的“年轻化”趋势十分明显,20~30岁患者的发病率呈上升趋势,因此,宫颈癌的病因学研究成为热点并取得了突破性的进展。宫颈癌的发生是多因素、多基因参与且呈多阶段发展的生物学过程,人乳头瘤病毒的感染被公认为宫颈癌的主要发病因素,但并不是唯一的因素。原癌基因c- Cervical cancer is the second most serious malignant tumor that seriously threatens the health of women. Its morbidity and mortality in developing countries account for about 15% of all malignant tumors in women, seriously affecting the quality of life of women and their families. In recent years, the prevalence of cervical cancer “young” trend is very obvious, the incidence of 20 to 30-year-old patients showed an upward trend, therefore, etiology of cervical cancer has become a hot spot and made a breakthrough. Cervical cancer is a multi-factor, multi-gene involved and multi-stage biological process of development, human papillomavirus infection is recognized as the main risk factor for cervical cancer, but not the only factor. Proto-oncogene c-