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目的：评估地佐辛联合丙泊酚在无痛电子胃镜检查中的临床效果和安全性。方法选择拟在丙泊酚静脉麻醉下行无痛电子胃镜检查的患者90例，随机分为D组（地佐辛＋丙泊酚组）、F组（芬太尼＋丙泊酚组），P组（丙泊酚组）每组30例。D组患者静脉注射地佐辛0.05 mg.kg-1，F组患者静脉注射芬太尼1μg.kg-1，3 min之后三组以效应室浓度为2.0μg/mL-1靶控注射丙泊酚，待BIS值降至70时开始胃镜检查。比较三组患者用药前（T0），麻醉后2 min（T1）及BIS达90时（T2）的HR、MAP、SpO2、RR的变化及不良反应发生情况。结果三组间丙泊酚用药量、苏醒时间差异有统计学意义（P＜0.05）。T1时D组、F组、MAP、HR、SpO2、RR较P组差异有统计学意义，D组、F组间SpO2、RR差异有统计学意义（P＜0.05）。结论0.05 mg.kg-1地佐辛在丙泊酚电子胃镜检查中具有良好的临床效果，可以减少丙泊酚用药量和呼吸抑制。“,”Objective To investigate the effect and safety of dezocine in propofol painless gastroscopy. Methods A total of 90 patients (ASA I orⅡ) who underwent painless gastroscopy with propofol were randomly divided into three groups, group D (dezocine + propofol), group F (fentanyl + propofol) and group P (propofol), n=30. Group D was injected dezocine 0.05 mg.kg-1 intravenously while Group F was injected fentanyl 1 μg.kg-1 intravenously. Three minutes later all three groups were injected with propofol TCI with 2.0μg.ml-1 effect site concentration, and were started examination when the BIS reduced to 70. Their respective HR, MAP, SpO2, RR and adverse events were compared before anesthesia (T0) was given, 2 minutes after anesthesia (T1) and the BIS raised again to 90 (T2). Results It reflected a statistical difference in propofol dosage and awakening time after the examination among three groups (P<0.05). Comparing with group P while in T1, the MAP、HR、SpO2、RR of T1 were higher in both group D and group F (P<0.05). Conclusion Dezocine 0.05mg.kg-1 combined with propofol is considered being effective and safe during the painless gastroscopy which limited propofol dosage, and reduced respiratory depression.