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目的研究IgA、IgM、IgG、C3、C4、可提取核抗原(ENA)、抗核抗体(ANAS)、抗双链脱氧核糖抗体(ds-DNA)几种免疫学抗体联合检测诊断系统性红斑狼疮的价值。方法对活动期系统性红斑狼疮、非活动期系统性红斑狼疮及健康者进行免疫学联合检测,并对比分析检测结果。结果系统性红斑狼疮活动组的IgA、IgM、IgG水平均明显高于健康者,差异有统计学意义(P<0.01),C3、C4指标明显低于健康者,差异有统计学意义(P<0.01);系统性红斑狼疮非活动组的IgA、IgG水平均高于健康者,差异有统计学意义(P<0.05),其余指标与健康者差异无统计学意义(P>0.05)。结论免疫学检验联合检测对于诊断系统性红斑狼疮具有临床参考价值,可用于判断系统性红斑狼疮的病情进展。
Objective To study the diagnostic value of IgA, IgM, IgG, C3, C4, ENA, ANAS and ds-DNA in the diagnosis of systemic lupus erythematosus the value of. Methods Immunological detection of active systemic lupus erythematosus, inactive systemic lupus erythematosus and healthy controls were performed, and the results were compared. Results The serum levels of IgA, IgM and IgG in patients with systemic lupus erythematosus were significantly higher than those in healthy controls (P <0.01). The indexes of C3 and C4 in patients with systemic lupus erythematosus were significantly lower than those in healthy controls (P < 0.01). IgA and IgG levels in inactive IS patients were significantly higher than those in healthy controls (P <0.05). There was no significant difference between other indexes and healthy controls (P> 0.05). Conclusion The combination of immunological tests for the diagnosis of systemic lupus erythematosus with clinical reference value, can be used to determine the disease progression of systemic lupus erythematosus.