七十年代初在上海医工院发现磷酸喹哌对实验性矽肺具有防治效果的基础上,我所于1974年初先后选择24例矽肺进展迅速的病人开始临床研究,24例均为男性,年龄37～62岁、Ⅱ、Ⅲ期各12例,全程讫今已10年观察证明:(1) 经治疗后约有14～41％患者气急、胸痛、咳嗽、咳痰有不同程度的 In the early seventies, Shanghai Medical College found that Quipfam phosphate had a preventive and therapeutic effect on experimental silicosis. In the beginning of 1974, we selected 24 patients with rapidly progressing silicosis to start clinical studies. All 24 patients were male and 37 ~ 62 years old, Ⅱ, Ⅲ in 12 cases, the entire process has been observed for 10 years to prove: (1) after treatment, about 14 ~ 41% of patients with shortness of breath, chest pain, cough, sputum have varying degrees of