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白血病人的淋巴细胞在含10~(-7)M(0.04微克/毫升)～10~(-6)M秋水仙碱的培养基中作体外培养1天, 其中死亡的细胞称为“秋水仙碱超敏感细胞”(Colchicine-ultrasensitive Lymphocytes,CUL),残存的活细胞称为“外观正常”细胞。后者和健康人的淋巴细胞群相似,需秋水仙碱浓度高达10~(-2)M,才能在1天之内被杀灭(较CUL高1～10万倍)。通常健康人淋巴细胞中CUL为数不足10％。其中也包括没有秋水仙碱存在也要自然死亡的淋巴细胞在内。慢淋时这种细胞常多于健康人。
Leukemic human lymphocytes were cultured in vitro for 1 day in medium containing 10 ~ (-7) M (0.04 μg / ml) ~ 10 ~ (-6) M colchicine. The dead cells were called “ Colchicine-ultrasensitive Lymphocytes (CUL), the remaining viable cells are called ”normal looking" cells. The latter is similar to a healthy human lymphocyte population and requires colchicine concentrations up to 10 -2 M to be killed within 1 day (1 to 100,000 times higher than CUL). Normally, the number of CUL in healthy human lymphocytes is less than 10%. These also include lymphocytes that naturally die without the presence of colchicine. Cile more often when the cells than healthy people.