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目的:探讨两种不同微创手术方式治疗胆囊结石合并胆总管结石的临床效果。方法胆囊结石合并胆总管结石患者83例,其中采用腹腔镜胆囊切除术(laparoscopic cholecystecto-my,LC)联合腹腔镜胆总管探查术(laparoscopic common bile duct exploration,LCBDE)(LC + LCBDE组)治疗胆囊结石合并胆总管结石的患者46例,内镜下逆行胰胆管造影( endoscopic retrograde cholangiopancreatography,ERCP)及乳头括约肌切开取石术( endoscopic sphincterotomy,EST)ERCP/EST + LC(ERCP/ EST + LC 组)治疗胆囊结石合并胆总管结石的患者37例,比较两组患者的临床治疗情况,包括手术成功率,中转开腹率,术后并发症的发生率,近期结石复发率,住院费用及时间等。结果两组患者的手术成功率(93.5% vs 89.2%),中转开腹率(6.5% vs 5.4%),术后并发症的发生率(8.7% vs 8.1%),近期结石复发率比较(5.2% vs 7.4%),差异均无统计学意义(P >0.05),手术时间,住院时间及治疗费用等比较差异有统计学意义( P 0. 05). There were significant statistical differences in the operation time,hospitalization charge and hospital stay between the two groups(P < 0. 05). Conclusion Both LC + LCBDE and ERCP/ EST + LC are effective therapies for patients with cholecystolithiasis and choledocholithiasis. LC combined with EST can shorten patients’time of the operation,but LC + LCBDE is superior in hospitalization charge and hos-pital stay. Because of different indications of these two minimally invasive surgical procedures,individual-ized treatment programs should be developed according to personal condition.