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西沙必利是一种新型的胃动力性药物,通过肠肌层神经丛释放乙酰胆碱而起作用,其效果比甲氧氯普胺强100倍,可增强胃部收缩,增加胃的张力,改善胃窦部和十二指肠的协调作用,加速胃排空,缩短胃肠道内半固体或固体食物的转运时间,且无抗多巴胺副作用。可用于糖尿病性胃麻痹、胃手术后、胃溃疡、慢性胃炎、胃食管返流、返流性食管炎、食管下段括约肌功能障碍及全身性神经肌肉疾病所致胃排空延迟的疾病。
Cisapride is a novel gastric motility drug that acts by releasing acetylcholine through the myenteric plexus, which is 100 times more potent than metoclopramide and enhances gastric contractions, increases gastric tension, improves gastric Sinus and duodenal coordination, accelerate gastric emptying, shorten the transit time of semi-solid or solid food in the gastrointestinal tract, and no anti-dopamine side effects. It can be used for diseases of delayed gastric emptying caused by diabetic gastric paralysis, gastric surgery, gastric ulcer, chronic gastritis, gastroesophageal reflux, reflux esophagitis, dysfunction of lower esophageal sphincter and systemic neuromuscular diseases.