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目的:分析同型半胱氨酸(Hcy)和血脂在不同年龄段冠心病患者中的应用价值,以期早期预测冠心病的发生。方法:选取确诊的冠心病患者150例,年龄28～85岁,平均(55.8±6.5)岁。患者空腹12h后采集静脉血,行血脂和Hcy检测,记录TC、TG、HDL-c、LDL-c和Hcy结果。同时,选取冠心病造影阴性者150例为对照组,年龄30～78岁,平均(53±6.5)岁。比较各组相关参数差异。结果:患病组TC、TG、LDL-c、Hcy均高于对照组,差异有统计学意义(P<0.05)。患者年龄越大Hcy和血脂值越高,A组TC、TG、HDL-c、LDL-c和Hcy值均低于C组,差异有统计学意义(P<0.05)。患病组C组TC、TG、HDL-c、LDL-c和Hcy值均高于对照组中C组,差异有统计学意义(P<0.05);A组和B组Hcy值分别高于对照组中A组和B组,差异有统计学意义(P<0.05)。结论:Hcy和血脂与冠心病的发生关系密切,患病年龄越大,Hcy和血脂值越高,对45岁以上的冠心病患者有独特的预测价值。
Objective: To analyze the value of homocysteine (Hcy) and lipids in patients with coronary heart disease at different ages so as to predict the occurrence of coronary heart disease in the early stage. Methods: A total of 150 patients with coronary heart disease were selected, aged from 28 to 85 years (mean, 55.8 ± 6.5) years. Venous blood was collected 12h after fasting, and blood lipid and Hcy were measured. The results of TC, TG, HDL-c, LDL-c and Hcy were recorded. At the same time, 150 patients with negative coronary angiography were selected as the control group, aged from 30 to 78 years, with an average of (53 ± 6.5) years. Compare the differences of relevant parameters in each group. Results: The prevalence of TC, TG, LDL-c and Hcy in the sick group were significantly higher than those in the control group (P <0.05). The older the patients were, the higher the Hcy and the lipids were. The levels of TC, TG, HDL-c, LDL-c and Hcy in group A were lower than those in group C, the difference was statistically significant (P <0.05). The levels of TC, TG, HDL-c, LDL-c and Hcy in group C were significantly higher than those in group C (P <0.05), while the values of Hcy in group A and group B were higher than those in group C Group A and group B, the difference was statistically significant (P <0.05). Conclusion: Hcy and blood lipids are closely related to the occurrence of coronary heart disease. The higher the prevalence of disease, the higher the Hcy and blood lipids, and have a unique predictive value for patients over 45 years of age with coronary heart disease.