甲氰咪胍属咪唑类化合物,在H_2受体阻断剂中其抑酸作用较强而副作用较少,广为临床应用。自1977年以来,临床上多用于治疗消化性溃疡、溃疡性结肠炎、上消化道出血、荨麻疹等。近年来报道其中副作用达5％～24％。为引起临床重视、合理用药,减少不良反应,现对甲氰咪胍常见的不良反应综述如下。 1、消化系统不良反应 1.1 胃肠道常见有腹泻、便秘、恶心、呕吐、口苦、口干、胃纳差等,其不良反应达18.9％。 1.2 应用甲氰咪胍4～6周后,3.6％患者有轻度谷丙转氨 Cimetidine imidazole compounds, H 2 receptor blocker in its strong acid-suppressing effect with fewer side effects, widely used in clinical. Since 1977, clinically used for the treatment of peptic ulcer, ulcerative colitis, upper gastrointestinal bleeding, urticaria and so on. In recent years, one of the side effects reported up to 5% to 24%. In order to attract clinical attention, rational use of drugs, reduce adverse reactions, are common to cimetidine common adverse reactions are summarized below. 1, digestive system adverse reactions 1.1 gastrointestinal tract common diarrhea, constipation, nausea, vomiting, mouth bitter, dry mouth, poor appetite and other adverse reactions up to 18.9%. 1.2 application of cimetidine 4 to 6 weeks, 3.6% of patients with mild alanine transaminase