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目的探讨联合放、化疗肝脏原发性神经内分泌癌伴脑转移治疗价值。方法首先行肝脏穿刺活检,确诊为原发性内分泌癌Ⅲ级,应用伽玛刀治疗,总剂量30 Gy,然后进行2个疗程肝脏介入治疗(5-Fu1000mg,MMC8mg,DDP80mg,ADM40mg),一次全身化疗。结果转移癌病灶缩小,一年后脑内又有新病灶出现。肝脏原癌性肿块得到控制,病人生存两年。结论肝脏原发性神经内分泌癌,经过恰当放化疗后,病情可稳定,大大地延长生存期。
Objective To investigate the value of combined radiotherapy and chemotherapy for primary neuroendocrine carcinoma of the liver with brain metastasis. Methods First liver biopsy was diagnosed as primary endocrine carcinoma grade Ⅲ, gamma knife treatment, the total dose of 30 Gy, and then two courses of interventional treatment of liver (5-Fu1000mg, MMC8mg, DDP80mg, ADM40mg), a whole body Chemotherapy. The results of metastatic cancer shrinkage, one year after the brain there are new lesions appear. Liver cancer was controlled mass, the patient survived two years. Conclusions Primary neuroendocrine carcinoma of the liver, after appropriate radiotherapy and chemotherapy, can be stable and greatly prolong the survival period.