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目的:探讨心踝血管指数(cardio-ankle vascular index,CAVI)与心血管危险因素的相关性,为早期干预提供依据。方法:对5458例受检者进行CAVI、腰围、体质量指数、血压、尿素氮、肌酐、空腹血糖、血浆总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇的检测;根据CAVI正常与否将研究对象分为CAVI异常组(CAVI≥9.0 m/s)和CAVI正常组(CAVI<9.0 m/s),用t检验、卡方检验比较组间临床和生化资料,运用logistic回归分析CAVI的相关影响因素。结果:CAVI异常组年龄[(65.24±10.28)岁]、男性比例(71.68%)、腰围[(84.39±7.51)cm]、空腹血糖[(6.14±1.81)mmol/L]、糖尿病比例(22.82%)、尿素氮[(5.84±1.73)mmol/L]、肌酐[(75.16±22.35)mmol/L]、高血压比例(65.66%)均高于CAVI正常组,且差异有统计学意义(P<0.05)。多元logistic回归显示年龄、性别、空腹血糖、肌酐、血压是CAVI的独立影响因素(P<0.05)。结论:本研究显示增龄、高血糖、高血压和肌酐升高与CAVI显著相关,提示加强老年人动脉硬化筛查工作,有效控制血糖、血压、肌酐有利于延缓动脉硬化进展。
Objective: To investigate the relationship between cardio-ankle vascular index (CAVI) and cardiovascular risk factors and provide basis for early intervention. Methods: The levels of CAVI, waist circumference, body mass index, blood pressure, blood urea nitrogen, creatinine, fasting blood glucose, plasma total cholesterol, triglyceride, high density lipoprotein cholesterol and low density lipoprotein cholesterol in 5458 subjects were measured. The subjects were divided into CAVI normal group (CAVI≥9.0 m / s) and CAVI normal group (CAVI <9.0 m / s) with or without normal CAVI. T-test and Chi-square test were used to compare the clinical and biochemical data between groups. Regression analysis of CAVI related factors. Results: The average age of patients with CAVI abnormalities was (65.24 ± 10.28) years old, male ratio was 71.68%, waist circumference was 84.39 ± 7.51 cm, fasting blood glucose was 6.14 ± 1.81 mmol / L, and diabetes was 22.82% (5.84 ± 1.73) mmol / L], creatinine (75.16 ± 22.35 mmol / L), and hypertension (65.66%) were significantly higher than those in normal CAVI group (P < 0.05). Multivariate logistic regression showed that age, sex, fasting blood glucose, creatinine and blood pressure were the independent influential factors of CAVI (P <0.05). Conclusion: This study shows that age, hyperglycemia, hypertension and elevated creatinine are significantly associated with CAVI, suggesting that strengthening the screening of elderly patients with atherosclerosis, effective control of blood glucose, blood pressure, creatinine is conducive to delay the progress of atherosclerosis.