目的研究骨髓增生异常综合征编码中出现的问题及对策。方法分析D46.0与D46.4的区别,FAB、WHO分型方案的变化,探讨儿童骨髓增生异常综合征的分类标准。结果分别用ICD-10、ICD-O(第三版)对FAB、WHO(2001版和2008版)该病各亚型进行编码。结论编码员应熟悉ICD-10中所采用的疾病分类体系并了解临床分类发展现状,以便对疾病进行准确的编码。 Objective To study the problems and countermeasures in the coding of myelodysplastic syndromes. Methods The differences of D46.0 and D46.4, the changes of FAB and WHO classification schemes were analyzed, and the classification criteria of children with myelodysplastic syndromes were explored. Results The subtypes of FAB, WHO (2001 version and 2008 version) were coded by ICD-10 and ICD-O (third edition) respectively. Conclusion The coder should be familiar with the disease classification system used in ICD-10 and understand the current status of clinical classification in order to accurately encode the disease.