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目的 探讨真胰岛素 (trueinsulin ,TI)测定在分析 2型糖尿病胰岛 β细胞功能中的意义。 方法 采用双位点夹心放大酶联免疫分析法 (BA -ELISA)及放射免疫分析法 (RIA)对 43例NGT、2 0例IGT及 47例 2型DM患者进行血清TI等的测定 ,初步分析其胰岛β细胞功能。 结果 肥胖的 2型DM及IGT患者血清空腹TI水平不高 (P >0 0 5 ) ,而免疫反应性胰岛素(IRI)则明显升高 (P <0 0 1) ,OGTT 30min及 6 0minTI水平明显低于NGT组 (P <0 0 1)。结论 2型DM患者的高胰岛素血症可能是高胰岛素原血症 ;TI测定较IRI更能确切地评价 β细胞功能及胰岛素敏感性。
Objective To investigate the significance of trueinsulin (TI) assay in the analysis of pancreatic β-cell function in type 2 diabetic patients. Methods Two hundred and seventy NGT patients, 20 IGT patients and 47 DM patients with type 2 diabetes mellitus were measured by double-site sandwich enzyme-linked immunosorbent assay (BA-ELISA) and radioimmunoassay (RIA) Its islet beta cell function. Results Serum fasting TI was not high in obese type 2 DM patients and IGT patients (P <0 05), while the IRI was significantly increased (P 0 01). The level of OGTT 30 min and 60 min was significantly higher Lower than NGT group (P <0.01). Conclusions Hyperinsulinemia in patients with type 2 diabetes may be hyperinsulinism; TI may be more accurate in assessing β-cell function and insulin sensitivity than IRI.