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目的分析偏头痛患者脑白质病变和认知功能特点。方法偏头痛组(n=60)和健康对照组(n=46)均行头MRI和P300的检查,观察有无脑白质变性和P300潜伏期和波幅的变化。并分析脑白质变性组偏头痛患者P300的变化。结果①偏头痛组头MRI显示12例脑白质内等或稍长T1,长T2信号;对照组有3例脑白质内异常信号。②偏头痛组患者P300的潜伏期显著长于正常对照组,波幅显著低于正常对照组。③偏头痛组患者脑白质异常者P300潜伏期显著长于头MRI正常偏头痛患者,波幅显著低于头MRI正常偏头痛患者。结论偏头痛患者可能存在脑白质变性和认知功能障碍,脑白质病变加重了认知功能障碍。
Objective To analyze the characteristics of white matter lesions and cognitive function in patients with migraine. Methods The head MRI and P300 were performed in the migraine group (n = 60) and the healthy control group (n = 46), and the changes of cerebral white matter degeneration and the latency and amplitude of P300 were observed. The changes of P300 in migraineurs with white matter degeneration were analyzed. Results ① Head MRI in migraine head showed 12 cases of leucorrhea within the same or slightly longer T1 and T2 signals, and 3 cases of abnormal signals in the control group. ② The latency of P300 in migraine group was significantly longer than that in the normal control group, and the amplitude was significantly lower than that in the normal control group. ③ The P300 latency of patients with white matter abnormalities in patients with migraine was significantly longer than that of migraine patients with normal MRI, and the amplitude of P300 was significantly lower than that of migraine patients with normal MRI. Conclusions Migraine patients may have white matter degeneration and cognitive dysfunction, and leukoaraiosis aggravates cognitive dysfunction.