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目的通过对不同年龄段健康儿童血清骨钙素（ＢＧＰ）含量的测定，评价正常儿童的骨骼生长发育时血清ＢＧＰ的含量，为代谢性骨病的诊断、治疗提供理论依据。方法用放射免疫的方法检测１０００名１１４岁的健康儿童血中ＢＧＰ的含量。结果 １１４岁小儿血清ＢＧＰ的含量在１０．６００－２４．８６６ｎｇ／ｍｌ之间，随着年龄增长，含量增加，青春期达高峰，１３组女孩血清ＢＧＰ含量明显高于男孩（Ｐ＜０．０１）。４７岁组男、女血清ＢＧＰ含量无差别，７１２岁组，女孩血清ＢＧＰ含量明显高于男孩（Ｐ＜０．０５）。女孩血清ＢＧＰ在８岁后明显升高，１３岁以后呈平台期。男孩血清ＢＧＰ在１２岁以后迅速增加。结论儿童血清ＢＧＰ含量（与年龄及身高的增长呈正相关。）在不同的生长发育时期，与性别有关。ＢＧＰ的测定可以评价正常儿童的骨骼生长发育状况，在代谢性骨病的诊治中具有重要意义。
OBJECTIVE: To evaluate the serum BGP level in healthy children at different ages and to evaluate the level of serum BGP during the bone growth and development of normal children, so as to provide a theoretical basis for the diagnosis and treatment of metabolic bone disease. Methods The levels of BGP in blood of 1000 114-year-old healthy children were detected by radioimmunoassay. Results Serum BGP levels of 114-year-old children ranged from 10.600 to 24.866 ng / ml, with the increase of age, the content of BGP increased to peak in adolescence. The serum BGP levels in 13 girls were significantly higher than those in boys (P <0.01) . There was no difference in serum BGP between 47-year-old group and 72-year-old girl. The level of serum BGP was significantly higher in boys than in boys (P <0.05). Serum BGP in girls significantly increased after 8 years of age, a plateau after 13 years of age. Boys serum BGP rapidly increases after 12 years of age. Conclusions Serum BGP levels in children (positively correlated with age and height growth) are related to gender at different stages of growth and development. The determination of BGP can evaluate the normal children’s bone growth and development status in the diagnosis and treatment of metabolic bone disease is of great significance.