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[目的]观察消化性溃疡(PU)患者不同时段服用抗幽门螺杆菌(Hp)药物,Hp根除及溃疡愈合疗效。[方法]Hp感染的十二指肠溃疡患者105例,胃溃疡患者69例,随机分2组,第Ⅰ组治疗第1周起服用奥美拉唑20 mg/次及2种抗生素(克拉霉素500 mg/次,阿莫西林1 000 mg/次),均2次/d;第Ⅱ组第1周单纯服奥美拉唑,第2周加服2种抗生素,服用药物及方法同第Ⅰ组。[结果]第Ⅱ组服药后Hp根除率为84.0%,较第Ⅰ组79.4%明显升高,溃疡和Hp复发率均下降(均P<0.05)。[结论]消化道症状缓解后服用抗生素Hp根除率高,溃疡复发率低。
[Objective] To observe the curative effect of anti-Helicobacter pylori (Hp), Hp eradication and ulcer healing in patients with peptic ulcer (PU) at different time. [Method] 105 patients with Hp-infected duodenal ulcer and 69 patients with gastric ulcer were randomly divided into 2 groups. Group 1 received omeprazole 20 mg once daily and two antibiotics The first week of group Ⅱ omeprazole alone, the first two weeks plus two antibiotics, taking the same drugs and methods with the first Group Ⅰ. [Result] The eradication rate of Hp in group Ⅱ was 84.0%, significantly higher than 79.4% in group Ⅰ, and the recurrence rate of ulcer and Hp was decreased (all P <0.05). [Conclusion] The eradication rate of antibiotics Hp after digestive tract symptom relief is high and the ulcer recurrence rate is low.