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目的:分析4种直肠给药剂型在直肠中的分布特点。方法:以亚甲蓝为指示剂,制备浓度均为0.5%的栓剂、灌肠液、凝胶剂和泡沫剂,将12只家兔分为4组,将4种制剂分别经直肠给药,2h后解剖,观察家兔直肠染色部分的长度、染色的深度、黏膜皱襞是否染色及制剂在体内保留时间等指标。结果:4种剂型中,泡沫剂组着色部分最长,平均达(28.3±1.3)cm(P<0.05),且颜色最深;栓剂组着色部分最短,平均为(12.5±0.8)cm,且颜色最浅,但制剂保留时间较长。凝胶剂组与灌肠液组着色长度和保留时间介于上述2种剂型之间。结论:泡沫剂在治疗直肠结肠疾病给药方面具有显著优势,值得深入研究。
Objective: To analyze the distribution characteristics of four rectal dosage forms in the rectum. Methods: With methylene blue as indicator, suppositories, enemas, gels and foams were prepared at concentrations of 0.5%. 12 rabbits were divided into 4 groups. The 4 kinds of preparations were administered rectally, 2 h After the anatomy, observe the length of rectum stained rabbit, the depth of staining, mucosal folds and whether the staining and preparation in vivo retention time and other indicators. Results: In the four formulations, the lightening part of the foam group had the longest average of (28.3 ± 1.3) cm (P <0.05) with the deepest color. The shortest coloring part of the suppository group was (12.5 ± 0.8) cm and the color The most shallow, but the formulation retention time longer. The gel length and retention time between gel group and enema group were between the above two dosage forms. Conclusions: Foam has significant advantages in the treatment of colorectal diseases and deserves further study.