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目的调查韶关市孕妇孕早期、孕中期和孕晚期尿碘水平,探讨孕妇尿碘筛查的时机和指导科学补碘。方法采用单纯随机抽样法抽取韶关市孕妇462例,其中孕早期166例,孕中期88例,孕晚期208例,收集尿样进行尿碘检测,并追踪妊娠结局。结果 462例孕妇尿碘中位数为182.69μg/L,处于WHO推荐的适宜水平。其中碘适量占23.38%,碘缺乏及碘过量分别占40.48%和18.61%。孕早期、孕中期碘缺乏率引起不良妊娠结局高于孕晚期差异无统学意义(P>0.05),孕早期及孕中期比较差异无统计学意义(P>0.05)。妊娠结局正常组孕晚期尿碘分级≥500μg/L孕妇比例明显高于妊娠结局异常组,差异有统计学意义(P<0.05)。结论通过监测孕妇尿碘,使其在适宜范围内,可使补碘的收益大于其危害,减少不良妊娠结局的发生。
Objective To investigate the urinary iodine levels of pregnant women in early pregnancy, mid-pregnancy and late pregnancy in Shaoguan City and to explore the timing of urinary iodine screening in pregnant women and to guide scientific iodization. Methods 462 pregnant women were sampled from Shaoguan City by simple random sampling method. Among them, 166 were pregnant in the first trimester, 88 were in the second trimester and 208 were in the third trimester. Urinary samples were collected for urinary iodine detection and the pregnancy outcome was tracked. Results The median urinary iodine of 462 pregnant women was 182.69μg / L, which was in the appropriate level recommended by the WHO. Which accounted for 23.38% of iodine, iodine deficiency and iodine accounted for 40.48% and 18.61% respectively. In the first trimester of pregnancy, the incidence of adverse pregnancy induced by iodine deficiency rate in the second trimester was higher than that in the third trimester of pregnancy (P> 0.05). There was no significant difference between the first trimester and the second trimester (P> 0.05). The proportion of pregnant women whose pregnancy outcome was normal in the third trimester with urinary iodine grade≥500μg / L was significantly higher than that in the abnormal pregnancy group (P <0.05). Conclusion By monitoring urinary iodine in pregnant women, making it within the appropriate range, the benefit of iodine supplement is greater than its harm and reduce the incidence of adverse pregnancy outcomes.