论文部分内容阅读
哥本哈根肝病研究组从1979年7月到1983年3月,用双盲对照法,在该市5个医疗中心对男性酒精性肝硬化患者进行了口服睾丸素(200mg一天三次)治疗的临床疗效考核.酒精性肝硬化的男性患者体内睾丸素浓度可高可低,但雌激素与睾丸素的比值升高可能与病人的临床表现和代谢有关.文献提示使用男性同化激素可能对这些患者的预后起有利作用,但是以前的研究都不是随机双盲的,也未按病因和性别分组研究,故作者认为有必要通过随机双盲对照试验对此重新作出评价.为了更好地评价睾丸素可能具有的副作用,也考虑到睾丸素治疗可能产生的有利影响,治疗组与对照组(安慰剂)的比例是3∶2.327名连续入院的患者中仅
The Copenhagen Hepatology Study Group conducted a double-blind, controlled trial of the clinical efficacy of oral testosterone (200 mg three times a day) in patients with alcoholic liver cirrhosis at five medical centers in the city from July 1979 to March 1983 In men with alcoholic cirrhosis, testosterone concentrations may be high or low in the body, but elevated estrogen to testosterone levels may be related to the patient’s clinical presentation and metabolism.1 The literature suggests that the use of male anabolic hormones may contribute to the prognosis of these patients However, none of the previous studies were randomized, double-blind, and not grouped by etiology and gender, so the authors considered it necessary to re-evaluate this in a randomized, double-blind, controlled trial.2 In order to better assess the possible effects of testosterone Side effects, taking into account the likely beneficial effects of testosterone treatment, the ratio of the treatment group to the control group (placebo) was 3: 2.327 among the patients who were consecutively admitted