IKKβ(NF-κB抑制剂激酶β)依赖的NF-κB激活在急慢性炎症的转录调控过程中处于中心地位然而,Greten等对将IKKβ抑制剂作为抗炎候选药物的建议提出了质疑,他们研究时意外发现:由于IL-1β前体加工增强导致循环IL-1β的水平增加,小鼠骨髓细胞中IKKβ的靶向缺失或通过药理学手段抑 IKKβ (NF-κB inhibitor kinase β) -dependent NF-κB activation plays a central role in the transcriptional regulation of acute and chronic inflammation However, Greten et al challenge the use of IKKβ inhibitors as anti-inflammatory drug candidates, Unexpected findings: IKKβ targeted loss in mouse bone marrow cells due to increased processing of IL-1β precursors leading to increased levels of circulating IL-1β or pharmacological inhibition