论文部分内容阅读
目的 研究超抗原金黄色葡萄球菌肠毒素 (SEA)对荷瘤大鼠胃癌模型炎性介质影响。方法 采用人胃癌细胞 (MGC80 -3 )皮下接种建立大鼠胃癌模型 40只 ,实验组注射SEA ,对照组注射生理盐水 ,检测大鼠体内炎性介质水平。结果 荷瘤大鼠模型SEA处理以后 ,血清IL 1β ,IL 6,IL 12 ,TNF α和内毒素水平均明显上升 ,与对照组相比差异有显著性 ,尤其以血清IL 1β内毒素水平上升明显 (P <0 .0 1)。结论 超抗原SEA可激活大量的T细胞 ,分泌多种细胞因子 ,直接或间接地杀伤肿瘤细胞。
Objective To study the effect of superantigen Staphylococcus aureus enterotoxin (SEA) on inflammatory mediators in gastric cancer model of tumor-bearing rats. Methods Forty gastric cancer models were established by subcutaneous inoculation of human gastric cancer cells (MGC80-3). SEA was injected into the experimental group and normal saline was injected into the control group. The levels of inflammatory mediators in the rats were measured. Results Serum levels of IL-1β, IL-6, IL-12, TNF-α and endotoxin were significantly increased after SEA treatment in tumor-bearing rat model, and the difference was significant compared with the control group, especially the level of serum IL- (P <0. 01). Conclusion Superantigen SEA can activate a large number of T cells, secrete a variety of cytokines, directly or indirectly kill tumor cells.